Imaris Learning: The Search - Cancer

The Search - Cancer

Cell–matrix interactions and the 3D cell migration

Speakers: Nicholas A. Kurniawan

Abstract: The search to discover a cure for cancer has been at the forefront of scientific research for many years. During this webinar we will look at how Imaris software from Bitplane has been used to analyse cell migration behavior, a key facet to better understanding how cancer works. Migration of cells is integral in various physiological processes in all facets of life. These range from embryonic development, morphogenesis, and wound healing, to disease pathology such as cancer metastasis. While cell migratory behavior has been traditionally studied using simple assays on culture dishes, in recent years it has been increasingly realized that the physical, mechanical, and chemical aspects of the matrix are key determinants of the migration mechanism. In this presentation, we discuss the dynamic cell–matrix mechanical interactions that occur during cell migration, as well as their role and manifestations in determining the overall efficiency of migration.

Multimedia Library
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Publications Database
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances
A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion
Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo
Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction
Endocan Is Upregulated on Tumor Vessels in Invasive Bladder Cancer Where It Mediates VEGF-A-Induced Angiogenesis
Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly
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CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network12
Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis
A Novel 3D Fibril Force Assay Implicates Src in Tumor Cell Force Generation in Collagen Networks
Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy
Coherent angular motion in the establishment of multicellular architecture of glandular tissues
Erythropoietin Receptor Signaling Is Membrane Raft Dependent
High-Resolution Multiphoton Imaging of Tumors In Viv
Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle
"Inflammatory cues modulate the expression of secretory product genes, Golgi sulfotransferases and sulfomucin production in LS174T cells
Cellular Architecture Mediates DivIVA Ultrastructure and Regulates Min Activity in Bacillus subtilis Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

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